Titlebook: New Trends in Cancer for the 21st Century; Proceedings of the I Antonio Llombart-Bosch,Vicente Felipo Conference proceedings 2003 The Edito

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Ewing Tumor Biology: Perspectives for Innovative Treatment Approaches,genesis as implied by the high association of EFT with.fusions, strong selective pressure for maintenance of a correct reading frame in the tumors, and by experimental data confirming the transforming and tumorigenic potential of EWS-FLI1. Understanding the biology of.gene fusions and its interplay

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,Targeting PDGF Receptors in Cancer - Rationales and Proof of Concept Clinical Trials,id leukemia and gastrointestinal stromal tumors. In both of these examples the target protein was identified by an oncogenic, activating mutation. Imatinib mesylate is also a potent inhibitor of PDGFR kinase and is currently being evaluated for the treatment of chronic myelomonocytic leukemia and gl

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