Titlebook: New Therapies in Advanced Cutaneous Malignancies; Piotr Rutkowski,Mario Mandalà Book 2021 The Editor(s) (if applicable) and The Author(s),

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Molecular Landscape of Skin Carcinomas in cell cycle control (., .), signalling (., .) and differentiation (., .) are often?altered in SCCs.?In Merkel cell carcinomas (MCCs) mutations occur in ., ., . and in the PI3K-AKT pathway?genes. Aberrations in MCCs result from UV exposure as well as Merkel cell polyomavirus infection. It is worth

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Immunological Features of Melanoma: Clinical Implications in the Era of New Therapiesing immunotherapy of melanoma patients. Having a general understanding of the pathways driving melanoma antigenicity and immune escape would help in applying these unique therapeutics under optimized conditions, tailoring treatment on individual patient immune profiles.

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