Titlebook: New Insights Into Retinal Degenerative Diseases; Robert E. Anderson,Matthew M. LaVail,Joe G. Hollyf Book 2001 Kluwer Academic / Plenum Pub

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Chronic Administration of Phenyl N-,- Butylnitrone Protects the Retina Against Light Damagens expressed in either photoreceptor or retinal pigment epithelial cells. There is currently no treatment by which the primary disorder can be modified, although researchers around the world are working on different potential therapeutic approaches to treat retinal degenerations. These are based on

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Role of Pigment Epithelium-Derived Factor (PEDF) in Photoreceptor Cell Protection(RPE) cells and was shown to be made . by both fetal and adult RPE cells. After release from the RPE, PEDF binds to the glycosaminoglycans of the interphotoreceptor matrix,.,. placing it in a prime physical location to affect the underlying neural retina. The PEDF gene has been cloned, sequenced and

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Glycobiological Approach to Control of Retinal Degeneration direct injection of growth factors or neurotrophic factors into the eye delays photoreceptor degeneration in inherited retinal dystrophy (.) and light damage (.). Although a combination of different factors enhances the degree of photoreceptor survival (.), the effects of other types of agents shou

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A Multidisciplinary Approach to Investigating Optic Nerve Regeneration in the Goldfishine possible factors involved in this process. By monitoring goldfish behavior, we found two phases of recovery. Simple behavioral patterns such as tilting and turning return one month after optic nerve transection (fast recovery phase), whereas more complex behaviors such as schooling behavior requ

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Intact-Sheet Fetal Retinal Transplants can Repair Degenerated Retinastoreceptors and/or RPE, the remaining retina that connects to the brain can still be functional. Our hypothesis is that transplantation of intact sheets of fetal retina alone or together with its RPE has the potential to restore a damaged retina. The donor tissue is dissected from rat fetuses (embry

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