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Titlebook: New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids; Ana Escribano Cuesta Book 2013 Springer International Publis

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書目名稱New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids
編輯Ana Escribano Cuesta
視頻videohttp://file.papertrans.cn/666/665327/665327.mp4
概述Nominated as an outstanding Ph.D. thesis by the Institute of Chemical Research of Catalonia, ICIQ.A number of important publications in high profile chemistry journals have derived from this work.The
叢書名稱Springer Theses
圖書封面Titlebook: New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids;  Ana Escribano Cuesta Book 2013 Springer International Publis
描述Ana Escribano Cuesta‘s thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author‘s research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.
出版日期Book 2013
關(guān)鍵詞Antonio M; Echavarren; Cyclization of Alkynylindole; Cyclobutene Compounds; Gold Properties; Gold(I)-Cat
版次1
doihttps://doi.org/10.1007/978-3-319-00702-1
isbn_softcover978-3-319-03385-3
isbn_ebook978-3-319-00702-1Series ISSN 2190-5053 Series E-ISSN 2190-5061
issn_series 2190-5053
copyrightSpringer International Publishing Switzerland 2013
The information of publication is updating

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Approach Toward the Total Synthesis of Lundurines,. Lundurinesare a new type of alkaloids characterized by a cyclopropyl fragment embedded within a hexacyclic ring system that includes a 1.–azocine[5,4–.]indole ring unit. The key step in the total synthesis of lundurine A is a 8–.–. cyclization of the alkynylindole catalyzed by AuCl., which affords
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ves are to set the basis for the following treatment, and to add aspects to the common methods, where more general approaches can provide further information. The demonstration examples primarily give expressions for limit and buckling states, often interpreted as maximum forcing levels for the cons
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is parameter dependent property of one particular state, and not just a limit for a certain qualitative response of the structure. This view is introduced in loose terms already in this Chapter, and will be a theme for coming Chapters, where more comprehensive settings are introduced.
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