Titlebook: New Developments in Lipid-Protein Interactions and Receptor Function; K. W. A. Wirtz,L. Packer,J. P. Changeux Book 1993 Springer Science+B

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Lysophosphatidic Acid as a Lipid Mediator: Signal Transduction and Receptor Identificationwn products of several plasma membrane phospholipids act as signal molecules, i.e. as intracellular second messengers or as agonists that modulate cell function. Well known examples of phospholipid-derived signaling molecules include diacylglycerol, inositol trisphosphate and prostaglandins, which a

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Modulation of Opioid Receptor Function by Membrane Lipidsteins is influenced by properties of the lipid bilayer. Specifically, in numerous studies the function of membrane-bound enzymes, receptors and transport carriers was correlated with membrane fluidity, a biophysical property largely determined by membrane composition at a given temperature (Shinitzk

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A Pharmacological Approach to Identify Hormone Signaling Pathways Controlling Gene Regulation in ,genes. We describe a novel set of non-hydrolysable cAMP derivatives, which can selectively activate cell surface cAMP receptors (CAR) or the intracellular cAMP-dependent kinase (PKA), two putative target proteins for the effects of cAMP. Comparison of the affinities of these derivatives for CAR and

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Glycosyl-Phosphatidylinositol: Role in Neurotrophic Factors Signallingctors. Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3) are members of a family of structurally related proteins termed neurotrophins that promote the growth and survival of neurons in the central and peripheral nervous systems (for a review see Barde, 1

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Regulation of Gene Expression in Rodent Hepatocyteshe selective induction, expression and regulation of the activity of genes which are likely to encode for DNA-binding proteins or proteins that interact with them and control the transcription of several other genes (Blau, 1988). Thus a cascade of molecular interactions is initiated that will ultima

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Transcription Factor Crem: A Key Element of the Nuclear Response to cAMPom other cells and the environment. The plasma membrane is the external interface of the cell and bears many elements which are required for the primary analysis of such signals. Among these elements are membrane receptors which are able to interact specifically with a variety of compounds. Binding

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Three-Dimensional Structure of the Human Retinoic Acid Receptor-β DNA Binding Domain: Implications ftinoic acid acts through binding to nuclear retinoic acid receptors (RARs). RARs are members of a superfamily of ligand-inducible nuclear transcription factors which comprises receptors for steroid and thyroid hormones and vitamin D3 (Evans, 1988). Until now three different RAR genes have been ident

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