Titlebook: New Concepts in the Pathogenesis of NIDDM; Claes G?ran ?stenson,Suad Efendi?,Mladen Vranic Book 1993 The Editor(s) (if applicable) and The

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Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDMst NIDDM, signs of hormonal dysbalance as well as insulin resistance are evident (1,2). Of the hormonal disturbances, impaired glucose-stimulated insulin response from the B-cells stands out as the most important defect (1,3). However, altered A- and D-cell secretion of glucagon and somatostatin, re

硬化

Regulation of Cytoplasmic Free Ca2+ in Insulin-Secreting Cellsterplay between nutrients, hormones and neurotransmitters. Metabolism of glucose and other nutrients leads to ATP generation, closure of ATP-regulated K.-channels, depolarization, opening of voltage-activated L-type Ca.-channels, increase in [Ca.]. and insulin release (1,2). Hormones and neurotransm

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INERT

Molecular Genetics of NIDDM and the Genes for Insulin and Insulin Receptorance rate of NIDDM among monozygotic twins (90–95%) and the somewhat lower concordance in dizygotic twins (approx. 40%).. NIDDM also displays obvious familial aggregation. First degree relatives of NIDDM patients run a 40% lifetime risk of developing the disease, compared to a 10% risk in individual

BULLY

Autoregulation of Glucose Transport: Effects of Glucose on Glucose Transporter Expression and Cellulistance plays a major role in the reduction of glucose consumption by peripheral tissues, and many defects have been described in the function of insulin receptors (see chapter by Olefsky), indirect clinical and in vivo experimental observations suggest that hyperglycemia per se may participate in i

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Indirect Effects of Insulin in Regulating Glucose Fluxesr all the metabolic events that occur following insulin secretion or administration. A number of laboratories, including our own, have suggested that many of the known effects of insulin on glucose metabolism may be exerted partially via indirect pathways.. Cumulative evidence indicates that the ind

COKE

The Insulin-Antagonistic Effect of the Counterregulatory Hormones — Clinical and Mechanistic Aspectsabetic state under a variety of conditions. This can be beneficial to the diabetics when the hormones counteract the effect of an excessive insulin level, such as a hypoglycemia. However, under other situations they may be to a disadvantage since the glucose control deteriorates and the insulin requ