Titlebook: New Challenges for Cancer Systems Biomedicine; Alberto d’Onofrio,Paola Cerrai,Alberto Gandolfi Book 2012 Springer-Verlag Italia Srl. 2012

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Dynamic Simulations of Pathways Downstream of TGF,, Wnt and EGF-Family Growth Factors, in Colorectalferent specifically altered onco-proteins affected by excess of function. The dynamic behavior of the simulation seems quite reasonable, in terms of what is known about the physiology and the pathology of this signaling-network region. Preliminary experimental verification experiments look encouraging.

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Spatio-Temporal Modelling of Intracellular Signalling Pathways: Transcription Factors, Negative Feedters such that sustained oscillatory dynamics occur, consistent with available experimental measurements. In order to bridge the gap between . and . experiments we investigate more realistic cell geometries by using an imported image of a real cell as our computational domain.

雄偉

Glucose Metabolism in Multicellular Spheroids, ATP Production and Effects of Aciditymors. The last part of the paper is devoted to the phenomenon of acid mediated tumor invasion, which exploits the different resistance to acidity of tumor and of normal cells. In particular, a one dimensional model is discussed in which invasion takes the form of a travelling wave front.

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Cell-Cell Interactions in Solid Tumors — the Role of Cancer Stem Cells model and a cellular Potts model. Simulations of tumor growth with both techniques reveal that cancer stem cell-driven solid tumors grow as conglomerates of self-metastases, suggesting a robust biological phenomenon. The growth rate of the tumor is dependent on the complex interplay of the underlying model parameters.

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