Titlebook: New Approaches in Cancer Pharmacology: Drug Design and Development; Vol. II Paul Workman (Chairman),Maurizio D’lncalci (Co-Cha Conference p

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Introduction,cal principles, often innervated by modern molecular biology techniques, continues to offer valuable improvements to the design and optimal utilisation of the conventionally acting cancer drugs which remain the mainstay of current cancer chemotherapy.

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Experimental Models to Investigate Novel Anticancer Drugs,le for neoplastic transformation have been elucidated. This new scientific knowledge is becoming exploitable for the design of novel drugs, acting as specific inhibitors of these pathways. Various approaches to rational design are discussed elsewhere in this volume and in the previous monograph.

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Apoptosis and Cancer Therapy,ell death is also a significant result of tissue damage and a cause of disease [9]. Moreover, its induction is the goal of most current strategies for cancer therapy. Recently, new concepts have emerged related to the different types of cell death occurring in this wide variety of circumstances.

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Discovery of Improved Platinum Analogues,ed in mice, rats, guinea pigs, dogs and monkeys and the results predicted well for those toxicities subsequently found in man [4]. Nephrotoxicity was the major dose-limiting side effect in all species, accompanied by gastrointestinal, haematological and ototoxicities, together with severe emesis in dogs and monkeys [5-11].

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Conference proceedings 1994atment of cancer. There are two main reasons why such an initiative was considered necessary. Firstly, the teaching of oncology requires a rigorously multidisciplinary approach which is difficult for the Universities to put into practice since their system is mainly disciplinary orientated. Secondly

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