Titlebook: Neutralization of Animal Viruses; Nigel J. Dimmock Book 1993 The Editor(s) (if applicable) and The Author(s), under exclusive license to S

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Neutralization of Animal Viruses978-3-642-77849-0Series ISSN 0070-217X Series E-ISSN 2196-9965

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neurologist

Introduction,t is likely that viruses and the antibody system have evolved in response to reciprocally imposed selective pressures. Neutralization of viruses which only infect non-antibody-synthesizing hosts, while of considerable interest from a number of points of view is de facto without any such evolutionary

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Immunoglobulin G Neutralization by Inhibition of Attachment of Virus to the Cell,cur it would seem that the IgG has to bind directly to or close by the viral attachment site or to change its conformation so that it no longer functions. Table 1 includes only data which show some indication of direct proportionality between neutralization and inhibition of attachment. For this rea

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Immunoglobulin G Neutralization Which Does Not Inhibit Attachment of Virus to the Cell,he appropriate sections below. As far as is known Table 3 excludes attachment which is peculiar to virus-IgG complexes, although evidence that non-neutralized and neutralized virus use the same receptor is rarely available. This has been demonstrated by competition for attachment between neutralized

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Immunoglobulin G Neutralization by Aggregation of Virions,y . (1968), and there are later discussions by . and . (1979), . and . (1979), . and . (1984) and . and . (1990). A priori, the number of infectious units is reduced when virus is aggregated, and this can be achieved by any antibody which recognizes a virion epitope, be it intrinsically neutralizing

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Neutralization Which Occurs by Virus Binding Antibody After It Has Attached to a Cell,tachment to cells is inhibited by IgG (Table 1) are not neutralized in this way, and indeed this is a criterion often used to define post-attachment neutralization. However, although mab to VP8*, the trypsin cleavage product of VP4 of rhesus monkey rotavirus, blocks attachment it also has the capaci

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