Titlebook: Neurotropic Viral Infections; Volume 2: Neurotropi Carol Shoshkes‘Reiss Book 2016Latest edition Springer International Publishing Switzerla

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The Pathogenesis of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesisis the CD4. T lymphocyte: HTLV-1 is not neurotropic in the strict sense, because it does not infect neurons. Instead, HTLV-1 reaches the CNS via migration of infected lymphocytes across the blood–brain barrier (BBB), and this process is thought to initiate HAM/TSP. The risk of developing HAM/TSP ris

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HIVatric CNS abnormalities, and HIV-associated myelopathy (HAM). The evidence supporting current concepts of viral neuropathogenesis will be presented in this context and then the impacts of efficacious combined antiretroviral therapy (cART). Finally, the emerging problem of CNS viral compartmentalizat

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The Pathogenesis of Varicella-Zoster Virus Neurotropism and Infectionmouse model has provided a system for investigating molecular mechanisms of VZV pathogenesis. SCIDhu xenografts are infected with recombinant VZV mutant viruses that have targeted deletions or mutations of specific genes or their promoters, which enables the assessment of functions of VZV protein su

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Virus-Induced Demyelination: The Case for Virus(es) in Multiple Sclerosisents in MS as potential “triggers” of disease. Models of virus-induced demyelination will be discussed, with an emphasis on the recent interest in human herpesviruses and the role they may play in MS disease pathogenesis. Although we remain circumspect as to the role of any microbial pathogen in MS,

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Innate Immunity in Viral Encephalitisment across the blood brain barrier (BBB) of circulating neutrophils, natural killer, monocytes, macrophages, dendritic cells, and ultimately T lymphocytes to the site of infection are also hallmarks of innate responses to infections. These responding cells contribute their own secreted effector mol

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The Role of Bats as Reservoir Hosts of Emerging Neurovirusesviruses Japanese encephalitis and St Louis encephalitis viruses, two important mosquito-borne encephalitogenic viruses, and bats can assist in the dispersal and over-wintering of these viruses. Bats are also the reservoir hosts of progenitors of SARS and MERS coronaviruses, although other animals ac