Titlebook: Neurotrophic Factors; Franz Hefti Book 1999 Springer-Verlag Berlin Heidelberg 1999 Alzheimer′s disease.anatomy.brain.brain injury.cerebral

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Role of Neurotrophic Factors in Cerebral Ischemia,th in in vitro and in vivo models of hypoxic-ischemic CNS injury. Protection from neuronal cell death also leads to a better retention and recovery of neurological and behavioral functions. In this chapter, we review the potential role and utility of neurotrophic factors in the ischemically injured brain.

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0171-2004 the past two decades. This new broad research area has identified molecular mechanisms that regulate the morphological plasticity of the nervous system and, in con- sequence, discovered novel pharmacological approaches to manipulate these processes in disease states. The new, structural neuropharmac

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Book 1999wo decades. This new broad research area has identified molecular mechanisms that regulate the morphological plasticity of the nervous system and, in con- sequence, discovered novel pharmacological approaches to manipulate these processes in disease states. The new, structural neuropharmacology as d

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Neurotrophic Factors and Amyotrophic Lateral Sclerosis, review). As the cellular mechanisms underlying the various forms of human motoneuron disease (MND) are still incompletely understood, the embryonic form of motoneuron loss serves as an important model for these diseases.

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Molecular Anatomy of Neurotrophic Factors,eceptor complexes for ciliary neurotrophic factor (CNTF) and glial cell line-derived neurotrophic factor (GDNF), the tasks of ligand binding and downstream signaling are segregated among the different subunits (IP et al. 1992; . et al. 1993b; . et al. 1996; . et al. 1996) (Fig. 1).

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Strategies for Administering Neurotrophic Factors to the Central Nervous System,eurotransmitter production. The neurons derive neurotrophic support either by means of retrograde transport from the “target cells” they innervate or from anterograde trophic support of presynaptic terminals. Glial cells, like Schwann cells, astrocytes and oligodendrocytes do provide NFs as well.

Adornment

Neurotrophin Treatment of Peripheral Sensory Neuropathies,rgeted population in many ongoing clinical trials, including NGF. However, as will be illustrated below, neurotrophins, such as NGF, have the potential to be effective therapies for various types of peripheral sensory neuropathies, regardless of etiology.

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