Titlebook: Neurotrophic Factors; Alan A. Boulton,Glen B. Baker,Franz Hefti Book 1993 Springer Science+Business Media New York 1993

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Visualization and Quantitation of Neurotrophin mRNAs,, a phenomenon referred to as naturally occurring cell death (Hamburger, 1975). The neurons that survive this phase are those that form functional connections with their targets, competing successfully for a limited supply of a target-derived trophic factor (Barde, 1989). The concept of neurotrophic

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Production of Recombinant Neurotrophic Factors,istry and neurobiology, perhaps the most notable effect has been on work with nerve growth factor (NGF), and its related protein family members, brainderived neurotrophic factor (BDNF or NT-2), and neurotrophin3 (NT.-3). The potential of producing mg and larger quantities of these agents will expedi

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Nonhuman Primate Models in Trophic Factor Research,higher cognitive functions, including memory. These animals have several advantages over rodents. First, these species are our closest relatives, and many features of nonhuman primate behavior and brain biology closely resemble those identified in humans. Second, available evidence indicates that th

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Purification and Microsequencing of Neurotrophic Proteins,reme cell-type heterogeneity of the nervous system, suggest that many other neurotrophic proteins remain to be discovered that have roles in the life, differentiation, and death of other subsets of cells. This conclusion has led to increasingly intense efforts to discover new neurotrophic molecules.