Titlebook: Neurotransmitter and Dementia; C. G. Gottfries,S. Nakamura Conference proceedings 1990 Springer-Verlag Wien 1990 Alzheimer.CNS.alzheimer‘s

FLIC

978-3-211-82190-9Springer-Verlag Wien 1990

期滿

Neurotransmitter and Dementia978-3-7091-3345-3Series ISSN 0303-6995

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啤酒

Charitable

Some effects of CNS cholinergic neurons on memory,uscarinic antagonists, scopolamine and methyl-scopolamine, and the change in acetylcholine (ACh) output induced by these drugs. Initially we studied the effects of these drugs on the animals’ performance of a step-through passive avoidance task. We then measured the change in ACh levels after admini

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Changes of acetylcholine and choline concentrations in cerebrospinal fluids of normal subjects and using high-performance liquid chromatography with electrochemical detector coupled with liquid cation-exchange method. In normal volunteers, ACh concentration was decreased significantly from 40–50 years and Ch concentration was increased significantly from 50–60 years. CSF from patients with DAT re

可憎

,Disturbance of the 5-hydroxytryptamine metabolism in brains from patients with Alzheimer’s dementiaeduced concentrations of 5-HT and 5-hydroxyindoleacetic acid (5-HIAA). 5-HT-sensitive imipramine binding is reduced by almost 50%, indicating a loss of presynaptic 5-HT terminals. There also seems to be reduced tryptophan hydroxylase activity in some brain areas. In cerebrospinal fluid (CSF) from AD

neutral-posture

,CSF ,-endorphin, HVA and 5-HIAA of dementia of the Alzheimer type and Binswanger’s disease in the eients with dementia of the Alzheimer type (DAT) and in 16 patients suspected of having Binswanger’s disease (BD) by MRI, which sometimes resembles DAT clinically. These were classified into three stages according to severity of dementia, Stage 1 (mild dementia)-Stage 3 (severe dementia). CSF levels

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