Titlebook: Neurosteroids; A New Regulatory Fun Etienne-Emile Baulieu,Paul Robel,Michael Schumache Book 1999 Springer Science+Business Media New York 1

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Neuroactive Steroid Modulation of Neuronal Voltage-Gated Calcium Channels,lity. The modulation of Ca. channels controls the extent of Ca. entry and provides a way of regulating neuronal function. Multiple classes of VGCCs exist in both peripheral and central mammalian neurons, based on biophysical and pharmacological identification. Electrophysiological studies have descr

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Gonadal Hormone Regulation of Synaptic Plasticity in the Brain,rmones and endogenous growth factors and neurotransmitters. Receptors for steroid hormones and thyroid hormone were the first transcription regulators discovered for eukaryotic cells (.). Besides helping to catalyze the discovery of other transcription regulators (.,.), the steroid-thyroid hormone f

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Steroid Effects on Brain Plasticity,entral nervous system (CNS). The mechanism of action of hormonal steroids in the brain involves their binding to specific intranuclear receptors that then act as transcription factors for specific genes .. Furthermore, steroid hormones may modulate neuronal excitability by having rapid nongenomic ac

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Remarkable Memory-Enhancing Effects of Pregnenolone Sulfate with Pheromone-Like Sensitivity,injury, or aging, it is necessary to facilitate adaptive coupling among relevant functional processes by relieving rate-limiting constrictions in mutually shaping interactions among intracellular, intercellular, and extracellular components of the system .. My colleagues and I have performed many ex

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Gonadal Hormone Regulation of Synaptic Plasticity in the Brain,amily of receptors has provided an important tool for elucidating the sites and cellular mechanisms by which circulating hormones exert permanent develop-mental effects (e.g., sexual differentiation) and reversible and often cyclic effects on the mature brain (.).

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