Titlebook: Neuroglia in Neurodegenerative Diseases; Alexei Verkhratsky,Margaret S. Ho,Vladimir Parpura Book 2019 Springer Nature Singapore Pte Ltd. 2

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Evolution of Neuroglia,. Arguably, these non-neuronal cells evolve into a more diversified cell family than the neurones are. The first ancestral neuroglia appeared in flatworms being mesenchymal in origin. In the nematode . proto-astrocytes/supportive glia of ectodermal origin emerged, albeit the ensheathment of axons by

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Gliocrine System: Astroglia as Secretory Cells of the CNS,es in the extracellular space, around the nearby synapses and also those released at much farther locations in the CNS, by their cell surface receptors, get excited to then release their own signaling molecules. This contributes to the brain information processing, based on diffusion within the extr

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Physiology of Oligodendroglia,ction potentials. Oligodendrocytes arise from oligodendrocyte progenitor cells (OPCs) under the control of multiple factors, including neurotransmitters and other neuron-derived factors. A significant population of OPCs persists in the adult CNS, where they are often referred to as NG2-glia, because

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,Astroglia in Alzheimer’s Disease, in advance of the clinical symptoms. At the cellular level, the most dramatic is a demise of neurones. As astroglial cells carry out homeostatic functions of the brain, it is certain that these cells are at least in part a cause of Alzheimer’s disease. Historically, Alois Alzheimer himself has reco