Titlebook: Neurodevelopmental Pediatrics; Genetic and Environm David D. Eisenstat,Dan Goldowitz,Jerome Y. Yager Textbook 2023 Springer Nature Switzerl

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The History of Autism Spectrum Disorder and social and family history. In the 1960s–70s, researchers classified children by clusters of quantifiable and observable behaviours, establishing an evidence-informed understanding of ASD. Since the 1980s, clinicians and researchers have explored biologic associations, such as seizure disorders

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Epidemiologye underlying genetic, biological, or environmental risk factors. Although multiple hypotheses have linked variation in autism prevalence to factors, such as geography, race/ethnicity, nativity, and SES, there is currently no direct evidence to support these hypotheses. Indeed, testing such hypothese

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The Neuroradiology of Autism: Framing Neuroimaging Investigations of the Autistic Brain Based on the cognitive presentations, and imaging methodological caveats. The development of new imaging sequences, computational methods, conceptual frameworks, integration with genetics and animal model studies, and moving beyond a case–control design are key opportunities to elucidate the heterogeneous neuro

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Neuropathology of Autismibed. Immunologic-driven alterations have also been described, including a consistent increase in CD8+ T-cell lymphocytes in ASD subjects, and alterations involving the blood–brain barrier..Given that ASD is well established as a heritable psychiatric disorder in up to 50% of the cases, animal model

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Textbook 2023hree disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy.

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