Titlebook: Neurodegenerative Diseases; Clinical Aspects, Mo Daniela Galimberti,Elio Scarpini Book 2018Latest edition Springer International Publishing

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Neurodegeneration and Multiple Sclerosis,d Parkinson’s disease, as well as multiple sclerosis (MS), diabetes, and acute brain injury among many other conditions. This chapter discusses the clinical and pathophysiological features of neurodegeneration in MS.

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Genetics and Epigenetics in the Neurodegenerative Disorders of the Central Nervous System,will offer the biomedical sciences new insight for the study of neurodegenerative diseases, multifactorial complex, and rare diseases. In this chapter, an overview of the current genetic and epigenetic progresses in AD, FTD, PD, and ALS, reached by the application of the new genetic technologies, wi

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Genetic Risk Factors for Sporadic Frontotemporal Dementia,tive strategy is to perform genome-wide association studies (GWAS) to highlight risk-loci. These then need to be further genetically and functionally characterize through, for example, targeted re-sequencing and expression quantitative trait loci (eQTL), to name a few methods..This chapter focuses o

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,Fluid Biomarkers in Alzheimer’s Disease and Frontotemporal Dementia,rliest stages of neurodegenerative diseases, better biomarkers for distinct proteinopathies, and the creation of universally accepted guidelines specifying the role of fluid biomarkers in relation to clinical measures and neuroimaging findings.

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Neurodevelopmental and Neurodegenerative Alterations in the Pathophysiology of Schizophrenia: Focusdentify the roots of the disorder during brain development, with consequences that do not become clinically evident until adolescence or early adulthood. On the other hand, longitudinal cohort studies on schizophrenic patients demonstrated a progressive loss of grey matter, more evident in the front