Titlebook: Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders; Novel Strategies for Michael S. Ritsner,Abraham Weizman Bo

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Dehydroepiandrosterone, as Endogenous Inhibitor of Neuronal Cell Apoptosis: Potential Therapeutic Imenhancing neuronal development. Its production rate and levels in serum, brain and adrenals decrease gradually with advancing age. This decline was associated to age-related neuronal dysfunction and degeneration, suggesting a neuroprotective effect of endogenous DHEA against noxious agents. This hyp

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Neurosteroids in the Aging Brainhysiology and management of memory and aging conditions. The relevance of neurosteroids to aging conditions is multifactorial and encompass changes of a variety of neurosteroid levels including DHEA, DHEA-S, pregnenolone, allopregnanolone, estradiaol and progesterone. Age-related decline in neuroste

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Dehydroepiandrosterone and Pregnenolone Alterations in Schizophreniaon neuronal excitability and synaptic plasticity. They also have many other functions associated with response to stress, mood regulation and cognitive performance. Furthermore, these neurosteroids have been linked to, and their levels are altered in neuropsychiatric disorders. This chapter pays spe

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Neurosteroids in Cortical Development and the Etiology of Schizophrenia neural development and function. However, no one mechanism has yet been proposed that explains the entire pathology of the disorder. One pathway that is clearly involved, however, is signaling via GABA. Post-mortem investigations reveal deficits in GABA transmission and altered localization of some

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Neurosteroid Perturbation and Neuropsychiatric Symptoms in Schizophrenia: From the Mechanisms to theic) and neurodevelopmental alterations resulting in a disconnectivity in the brain. Since neurosteroids modulate neurotransmitter systems as well as growth factor expression implicated in schizophrenia, recent research has focused on examining the role that neurosteroids play in the illness phenomen

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Dehydroepiandrosterone Administration in Treating Medical and Neuropsychiatric Disorders the world have explored the therapeutic role of DHEA. This chapter provides the main facts on biological effects of DHEA administration followed by review of recently reported findings from DHEA clinical trials in schizophrenia. Alterations in DHEA metabolism in schizophrenia are not well understoo

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Allopregnanolone and Pregnenolone Alterations Following Pharmacological Agents in Rodents and Clinic disorders. A wide array of preclinical investigations also reports neuroactive steroid actions in areas relevant to neuropsychiatric conditions, including neuroprotection, neuroplasticity, and neurogenesis. Levels of several neuroactive steroids are altered following the administration of various p

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Reconsidering Classifi cations of Depression Syndromes: Lessons from Neuroactive Steroids and Evolutapable of modifying neural activities. NAS bind to and modulate different types of neurotransmitter receptors at the membrane level. The gamma-aminobutyric acid (GABA) and sigma receptor complexes have been the most extensively studied..After intracellular oxidation, tetrahydroprogesterone (THP) to

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