Titlebook: Neuraxial Therapeutics; A Comprehensive Guid Tony Yaksh,Salim Hayek Book 2023 Springer Nature Switzerland AG 2023 Intrathecal Drug Delivery

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Spinal Anatomy of Experimental Animals,odent species (rats). These species were chosen because of their extensive use as preclinical models for spinal drug delivery. Specific comments about the salient features of other animal species, including porcine, ovine, bovine, and primate, are also considered.

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Spinal Cord Vasculature: General Anatomy and Physiology,nd venules penetrate the parenchyma through the perivascular Virchow-Robin spaces, and the venous outflow exits through the intradural and extradural vessels and plexi. Species differences in this perfusion structure are compared and contrasted. Specific discussions of rostrocaudal flow patterns, sp

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Cerebrospinal and Interstitial Fluids: Production, Outflow, and Circulation, and interstitial fluid (ISF), which surrounds cells within the brain and spinal cord parenchyma. Although these fluids fulfill different primary roles in the CNS, their formation, exit from the CNS, and circulation are intimately linked. This chapter describes CSF production at the choroid plexuses

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Emerging Insights into the Interstitial Distribution of Neuraxial Therapeutics via the Cerebrospinasearch has brought to light physiological and pathological processes that regulate the movement of fluids and solutes between the cerebrospinal fluid (CSF) compartment and the CNS interstitium and may have important implications for neuraxial therapeutic delivery. Here, we review recent findings, su

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