Titlebook: Nested Simulations: Theory and Application; Maximilian Klein Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusive li

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Introduction,surance world is indispensable. Unfortunately, the concept of ‘radical uncertainty’, grounding on a non-stationary environment in economics and social sciences, must be admitted. The economic and financial crisis in 2008 and 2010 (Greek government-debt crisis) made unmistakably clear that a profound

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Basic Concepts, Probability Inequalities and Limit Theorems,st, explicit upper bounds on the deviation probability between r.v. averages, like . resp. ., and its corresponding mean are needed to establish in Chapter 3 and Chapter 4 the almost sure convergence results.

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Almost Sure Convergence of Moment-Based Estimators,based on the results of Klein and Werner (2023b). The corresponding research question is rather easy to postulate, i.e.: Which minimal growth condition on . and . leads to an uniform almost sure convergence of . towards .? Furthermore, the speed of convergence will also be examined.

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Numerical Analysis,on of an analytical solution for . in the moment- and . in the quantile-based case. Hence, such an example is especially relevant for our almost sure considerations because the illustration of a.s. rates requires at least an analytical solution. In the insurance specific part we introduce, first, an

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Maximilian Klein the primary neutralizing antibody response of the host is directed at linear versus complex epitopes or to V3 versus non-V3 determinants. Neutralization escape mutants appear to arise during the course of infection of single individuals, but the variable regions primarily responsible for this escap

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Maximilian Kleinze endogenous antigen in association with MHC class I molecules and display cytotoxic activity against infected or peptide-pulsed target cells. Although these cytotoxic T lymphocytes (CTL) have usually been described following infection with viruses or intracellular bacteria, they can also be induce

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