Titlebook: Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers; Multidisciplinary Ma Andrea Necchi,Philippe E. Spiess Book 2022 The

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Book 2022ed bladder cancer, renal cell carcinoma, and prostate cancer. The advent of immunotherapy has revolutionized treatments of genitourinary malignancy and evolved strategies for multidisciplinary management. This book explains neoadjuvant checkpoint inhibitors in localized genitourinary cancers, provid

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Pathologic Features of Response to Neoadjuvant Therapies in Muscle-Invasive Bladder Cancer: More thaof bladder cancer. Therefore, there is a growing interest to assess the morphologic changes associated with response to neoadjuvant treatments, with the aim to refine the prognostic reliability of complete pathologic response and to design specific histology-based scoring systems to predict immune checkpoint inhibitor’s therapeutic efficacy.

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Ongoing Trial and Clinical Trial Endpoint Debate: The Role of Pathologic Response as a Surrogate of are needed to confirm the efficacy of neoadjuvant immunotherapy-based approaches. Furthermore, work on establishing the surrogacy of pathologic endpoints for longer-term outcomes such as overall survival within immunotherapy-based studies is required before adoption of neoadjuvant immune checkpoint blockade into routine clinical practice.

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Cytoreductive Nephrectomy in the Era of Targeted Therapy and Immunotherapyystemic therapies by removing potential interactions between the tumor and metastases, (3) palliation of symptoms, and (4) many others [2]. However, the role of CN changed several times in the last decades due to the introduction in clinical practice of several systemic therapies which became available over the years.