Titlebook: Nature in Silico; Population Genetic S Ryan J. Haasl Textbook 2022 Springer Nature Switzerland AG 2022 Population genetics.Population genom

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Mutation and Genetic Drift, mutation, and we therefore begin by modeling mutation. Because all populations are necessarily finite, the frequencies of new and standing variants are impacted by sampling error each generation. This sampling error is a driver of random evolutionary change. In the absence of all other evolutionary

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Population Structure and Migration,ructured coalescent is used as an intuitive model for thinking about the fate of alleles in a population whose demes are connected by appreciable gene flow. The migration rate . is defined and its importance to genetic population structure is emphasized. Modifications to the code of forward-simulati

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Natural Selection,le positive natural selection is simulated first. Then more complicated scenarios including frequency-dependent selection and overdominance are considered. Selection on two-locus haplotypes is then discussed and simulated. Simulations in this section demonstrate the value of stochastic simulation wh

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Effects of Selection on Linked Variants,et site is embedded. Here, we amend and revise the prospective time simulator FORTUNA that we have developed throughout the text to include a selected site within the simulated sequence. This additional capacity allows us to use simulations to explore the effects of natural selection on linked, neut