Titlebook: Natural Products from Actinomycetes; Diversity, Ecology a Ravishankar V. Rai,Jamuna A. Bai Book 2022 The Editor(s) (if applicable) and The

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New Strategies to Activate Secondary Metabolism in ,ifferentiation but differentiation in liquid cultures still not fully understood, due to the fact that most . do not sporulate in these conditions. Here, we review the strategies to activate cryptic pathways in streptomycetes.

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Quorum Sensing and Quorum Quenching Metabolites in Actinomycetes,olactone characterized and studied was the A-factor. In recent years, several other γ-butyrolactones have been identified in different species of . and non-.. Apart from GBLs, certain actinomycetes also utilize peptides and antibiotics as signal molecules. In this chapter, we describe the quorum sen

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Application of CRISPR/Cas9 Editing for Production of Secondary Metabolites in Actinomycetes,ruction of CRISPR/Cas9-based editing platforms in actinomycetes. We have also discussed the advantages and limitations of the four CRISPR/Cas9-based toolkits in .. The potential application of CRISPR/Cas9 genome editing in actinomycetes for the?detection of cryptic BGCs and genes encoding novel seco

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Endophytic Actinomycetes: Secondary Metabolites and Genomic Approaches, in high-throughput genome sequencing techniques, many genome mining methods has been developed and helped to link the discovered compounds to their biosynthetic gene clusters (BGCs). This chapter highlights bioactive compounds derived from endophytic actinomycetes on their biological activity and b

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Glycopeptide Antibiotics: Genetics, Chemistry, and New Screening Approaches,n. In this chapter, we outline a comprehensive picture of GPAs, focusing on genetics and chemistry behind their biosynthetic pathways. Examples of the use of the gained knowledge for strain improvement and discovery of novel compounds are given. A concise outlook of bioactivities exhibited by GPAs w

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Biotechnological Aspects of Siderophore Biosynthesis by Actinobacteria, is to mobilize iron and selected other metal ions to supply the producing and secreting organism with nutrients. Thus, they allow microbes to colonize new habitats or maintain their metabolic activity even under limiting conditions. Siderophores provide access to various applications, and herein, w

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