Titlebook: Natural Compounds as Drugs, Volume II; Frank Petersen,René Amstutz Book 2008 Birkh?user Basel 2008 bacteria.cancer.drug.drug discovery.dru

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Activation of fungal silent gene clusters: A new avenue to drug discovery,h no actual product has been characterised. In many cases, these clusters remain silent under laboratory conditions. New technologies based on genetic engineering are available to induce silent genes. Heterologous expression of a silent gene cluster under the control of defined promoters can be appl

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Application of natural product-inspired diversity-oriented synthesis to drug discovery,tegies such as diversity-oriented synthesis (DOS) have enabled the synthesis of natural product-like compounds. The combination of these approaches has both improved the desired biological properties of natural products as well as the identification of novel compounds. Diversity concepts and strateg