Titlebook: NMR for Chemists and Biologists; Rodrigo J Carbajo,José L. Neira Book 2013 The Author(s) 2013 Biochemistry.Chemistry.Drug design.NMR.Prote

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2211-9353 view of the most recent and important biological applicatioThis book intends to be an easy and concise introduction to the field of nuclear magnetic resonance or NMR, which has revolutionized life sciences in the last twenty years. A significant part of the progress observed in scientific areas lik

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Spectroscopic Parameters in Nuclear Magnetic Resonance,are unique to the technique, arising from the properties described in the previous chapter. The origin and physical characteristics of the chemical shift, the spin–spin scalar coupling and the nuclear Overhauser effect (NOE) will be introduced here.

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Basic NMR Experiments,clear and heteronuclear shift correlation experiments based on scalar couplings are shown. The basis of the population transfer that is at the root of heteronuclear experiments is described. The chapter ends with the most relevant nuclear correlations via dipolar couplings, based on the NOE effect.

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Biomolecular NMR,n introduction to the analysis of biomolecular dynamics by NMR will also be described, as well as NMR applications in drug discovery and biomolecule-ligand interactions in general. Finally, the basic concepts behind solid-state NMR and metabolomics-by-NMR will be presented.

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The Basis of Nuclear Magnetic Resonance Spectroscopy,as well as a basic introduction to the theory and mechanisms of spin relaxation. The application of radiofrequency pulses to produce the NMR signal, its conversion to the frequency domain by Fourier Transform and the typical instrumental set-up of magnetic resonance are also covered.

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