Titlebook: NMDA Antagonists as Potential Analgesic Drugs; Dalip J. S. Sirinathsinghji,Ray G. Hill Book 2002 Springer Basel AG 2002 analgesics.brain.c

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Interaction of NMDA and other neurotransmitter receptor systems in modulation of nociception,an increasingly important target site for potential analgesics as evidence accumulates for a role of the receptor in the enhancement of spinal processing of painful messages [.-.] and in many long-term events in the brain, including long-term potentiation and excitotoxic cell death [., ., .].

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Spinal nociceptive processing: NMDA receptors and modulation by neuropeptides,ve information in the spinal cord (for review see [.]). Both of these neurotransmitters are released into the dorsal horn following noxious peripheral stimulation [.]. In the early 1960s it was found that glutamate and aspartate strongly excited spinal neurones [.] and that various analogues of thes

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