Titlebook: NF-κB-Related Genetic Diseases; Gilles Courtois,Alessandra Pescatore,Anna Senegas Book 2016 The Author(s) 2016 Genetic diseases.Immunodefi

endure

Euphonious

先驅(qū)

,The NF-κB Signaling Pathway: Players and Functions,tivation exist, a canonical one and a non-canonical one, both of them requiring intricate molecular interplays involving adaptor proteins and enzymes that control phosphorylation and ubiquitination events. This culminates in translocation of NF-κB in the nucleus and modulation of gene expression.

Directed

,Genetic Diseases Affecting Ubiquitination Processes in NF-κB Signaling,ain formation; TRAF6, a key regulator in immunity and skin appendages development; and CYLD, a deubiquitinase negatively regulating the NF-κB activation process at several levels. They provide an alternative entry point to analyze the consequences of deregulated NF-κB activity.

斗志

Communal

,Lessons Learned from Studying NF-κB-Related Genetic Diseases, for the same components and, on the other, to assign specific defects in humans to discrete molecular impairments. All these information should contribute to the design and validation of therapeutic treatments.

跳脫衣舞的人

Book 2016ted pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients acquire a deeper understanding of the molecular basis

Sad570

羊齒

,Genetic Diseases Affecting the Canonical Pathway of NF-κB Activation, pathologies caused by mutations of NF-κB subunits regulating exclusively the canonical pathway. They allowed to confirm the essential role of canonical NF-κB activation in innate and acquired immunity or inflammation but also revealed new functions of this pathway.

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