| 書目名稱 | Mouse as a Model Organism | | 副標題 | From Animals to Cell | | 編輯 | Cord Brakebusch,Taina Pihlajaniemi | | 視頻video | http://file.papertrans.cn/640/639729/639729.mp4 | | 概述 | High-level articles interesting for beginners and experienced scientists in mouse model research.Describes state-of-the-art, chances, and current problems in mouse model research In the post-genomic e | | 圖書封面 |  | | 描述 | Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gene mutations, the mouse has become the favourite mammalian model organism to study in vivo function of genes during development and in disease. This book combines review articles on selected subjects presented at the symposium “Mouse as a Model Organism – From Animals to Cells”, held in Rovaniemi, Finland, 2009. Among other topics, high-throughput phenotyping of mouse mutants, mouse phenotypes dependent on nature and nuture, and a spectrum of in vivo, ex vivo and in vitro methods to study cancer | | 出版日期 | Book 2011 | | 關鍵詞 | Animal Models; Biological Techniques; Genetic and Genomics; Mouse; Transgenics | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-007-0750-4 | | isbn_softcover | 978-94-007-9609-6 | | isbn_ebook | 978-94-007-0750-4 | | copyright | Springer Science+Business Media B.V. 2011 |
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