| 書目名稱 | Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 | | 編輯 | Eugene G. Hrycay,Stelvio M. Bandiera | | 視頻video | http://file.papertrans.cn/640/639040/639040.mp4 | | 概述 | This is the first book that provides up-to-date, comprehensive reviews on the monooxygenase, peroxidase and peroxygenase properties and mechanisms of cytochrome P450 enzymes in 13 chapters compiled by | | 叢書名稱 | Advances in Experimental Medicine and Biology | | 圖書封面 |  | | 描述 | .This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O.2. pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP19A1 and CYP51A1; metabolism of tetrabromodiphenyl ethers and bile acids by CYP2B6 and CYP3A4; metabolism of ω-6 and ω-3 polyunsaturated fatty acids; H.2.O.2.-mediated peroxygenation of substrates using substrate misrecognition; P450 oxidative reactions using electrochemical methods; electron transfer to P450 by redox proteins; hydroxylation of 1,8-cineole by P450cin; and peroxygenation by unspecific peroxygenases using H.2.O.2.. The topics covered are relevant to P450 researchers, professors and students from a variety of disciplines ranging from pharmacology, toxicology and microbiology to chemistry.. | | 出版日期 | Book 2015 | | 關(guān)鍵詞 | Cytochrome P450; Electron transfer proteins; Monooxygenase; Peroxide shunt; Peroxygenase | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-16009-2 | | isbn_softcover | 978-3-319-34794-3 | | isbn_ebook | 978-3-319-16009-2Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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