| 書目名稱 | Molecular Targeted Radiosensitizers | | 副標(biāo)題 | Opportunities and Ch | | 編輯 | Henning Willers,Iris Eke | | 視頻video | http://file.papertrans.cn/639/638532/638532.mp4 | | 概述 | Features chapters authored by a diverse array of established, internationally known and up-coming investigators including members of the NCI-funded Preclinical Chemo-Radiotherapy Testing Consortium (P | | 叢書名稱 | Cancer Drug Discovery and Development | | 圖書封面 |  | | 描述 | .Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers.. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth loo | | 出版日期 | Book 2020 | | 關(guān)鍵詞 | radiosensitizers; radiation oncology; tissue toxicity; targeting DNA damage response; immuno-oncology; me | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-49701-9 | | isbn_softcover | 978-3-030-49703-3 | | isbn_ebook | 978-3-030-49701-9Series ISSN 2196-9906 Series E-ISSN 2196-9914 | | issn_series | 2196-9906 | | copyright | Springer Nature Switzerland AG 2020 |
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