| 書目名稱 | Molecular Structures and Structural Dynamics of Prion Proteins and Prions |
| 副標(biāo)題 | Mechanism Underlying |
| 編輯 | Jiapu Zhang |
| 視頻video | http://file.papertrans.cn/639/638524/638524.mp4 |
| 概述 | Systemically studies the structures of prion proteins, especially the PrP models of resistant species to prion diseases (dog, rabbit, horse and buffalo).Introduces local and global search computationa |
| 叢書名稱 | Focus on Structural Biology |
| 圖書封面 |  |
| 描述 | .This monograph is the first easy-to-read-and-understand book on prion proteins‘ molecular dynamics (MD) simulations and on prions‘ molecular modelling (MM) constructions.? It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrP.C.) to diseased infectious prions (PrP.Sc.), using MD and MM techniques. As we all know, prion diseases, caused by the body‘s own proteins, are invariably fatal and highly infectious neurodegenerative diseases effecting humans and almost all animals for a major public health concern. Prion contains no nucleic acids and it is a misshapen or conformation-changed protein that acts like an infectious agent; thus prion diseases are called “protein structural conformational” diseases..PrP.C. is predominant in α-helices but PrP.Sc. are rich in β-sheets in the form as amyloid fibrils; so very amenable to be studied by MD techniques. Through MD, studies on the proteinstructures and the structural conversion are very important for revealing secrets of prion diseases and for structure-based drug design or discovery. Rabbits, dogs, horses and buffaloes are reported to be the few low susceptibility species to pr |
| 出版日期 | Book 2015 |
| 關(guān)鍵詞 | Molecular Modeling; Molecular Structures; Prion Amyloid Fibrils; Prion Diseases; Prion Proteins; Protein |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-94-017-7318-8 |
| isbn_softcover | 978-94-024-0445-6 |
| isbn_ebook | 978-94-017-7318-8Series ISSN 1571-4853 Series E-ISSN 2542-9566 |
| issn_series | 1571-4853 |
| copyright | Springer Science+Business Media Dordrecht 2015 |
|Archiver|手機(jī)版|小黑屋|
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