Titlebook: Microdomains in the Cardiovascular System; Viacheslav Nikolaev,Manuela Zaccolo Book 2017 Springer International Publishing AG 2017 microdo

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Subcellular Targeting of PDE4 in Cardiac Myocytes and Generation of Signaling Compartmentstion. Conversely, much less was known about the PDE4 family of proteins expression and function in the heart. Indeed, PDE4-selective inhibitors were developed with the rationale that they would retain the beneficial properties of a nonselective inhibitor but would be devoid of cardiac effects. Yet i

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Cardiac cAMP Microdomains and Their Modulation Using Disruptor Peptidesm the 11 families are selectively expressed and targeted in cellular microdomains, with each isoform’s function underpinned by its location, affinity/specificity of its cyclic nucleotide substrate, and ability to be modified by posttranslational modifications. The best way to define the function of

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Signalling Microdomains: The Beta-3 Adrenergic Receptor/NOS Signalosomerface receptors. This is achieved by spatial confinement of receptors and effectors in specific membrane locales, such as caveolae, but also by receptor translocation to particular plasma membrane locations upon ligand stimuli, cellular stress or pathophysiologic conditions, thereby changing downstr

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Distribution and Regulation of L-Type Ca2+ Channels in Cardiomyocyte MicrodomainsExcitation of the cellular membrane results in opening of the voltage-gated L-type Ca. channels, which allow a small amount of Ca. to enter the cell. This triggers the release of a much greater amount of Ca. from the intracellular Ca. store, the sarcoplasmic reticulum, and gives rise to the systolic

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