Titlebook: MicroRNAs as Tools in Biopharmaceutical Production; Niall Barron Book 2012 Springer Science+Business Media Dordrecht 2012 Bioprocessing.Ch

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A General Introduction to MicroRNAs, Their Investigation and Exploitation in CHO Cell Lines,eering in eukaryotic cell factories. In considering the wide influence of microRNAs, we place a special emphasis on the cellular effects associated with the manipulation of microRNA and high yield of protein production with reference to use in Chinese hamster ovary (CHO) expression systems.

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OREX

Biogenesis of Mammalian miRNA,subsequently exported out of the nucleus whereupon they are further processed by the RNase III enzyme Dicer resulting in the formation of a ~?20–24 nt miRNA duplex. Thermodynamic stability of each strand determines which strand of the miRNA duplex will be retained within the RNA-induced silencing co

artifice

Target Prediction Algorithms and Bioinformatics Resources for miRNA Studies, order to determine the impact of a miRNA on biological function. A range of popular miRNA target prediction algorithms are presented, their underlying principles described and performance assessed. In addition, publically available repositories of miRNA sequence, expression profiling and target dat

BIDE

The CHO miRNA Transcriptome,ttle attention has been attributed to miRNAs in the Chinese hamster, or the most widely used Chinese hamster derived cell line—Chinese hamster ovary (CHO) cells until recently. This is surprising, given the fact that miRNAs are known to orchestrate complex gene expression networks, thereby acting am

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消散

MicroRNAs for Enhancement of CHO Cell Proliferation and Stability: Insights from Neuroblastoma StudAs are significantly involved with cell proliferation, apoptosis, differentiation, senescence, cell migration and invasion in the context of both normal developmental processes and in malignant diseases. They can both promote or retard all of these cellular phenotypes, dependent on cellular context.

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