Titlebook: MicroRNA in Cancer; Suresh Alahari Book 2013 Springer Science+Business Media Dordrecht 2013 Breast cancer.MicroRNA.Oncogene.Tumor suppress

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MicroRNAs and Other Non-Coding RNAs: Implications for Cancer Patients,t do not encode proteins but interfere with translation and transcription, thereby regulating gene expression. Multiple miRNAs are dysregulated in human cancer, supporting the hypothesis that miRNAs are involved in the initiation and progression of cancer. Prototypic malignancies in which a role for

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Function of miRNAs in Tumor Cell Proliferation,of targeted messenger RNAs. According to the miRBase Sequence Database (http://www.mirbase.org/index.shtml), more than 1,000 miR sequences have been identified from the tissues or cells of human origin. miRNAs are transcribed from the genome mostly by RNA polymerase II into primary miRNAs (called pr

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MicroRNAs in Cancer Stem Cells,tionising our understanding of cancer cell biology. There is increasing evidence for a central role of microRNAs in control of the normal and malignant stem cell phenotype. This new understanding promises to open new avenues in cancer prognosis and therapy.

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MicroRNAs in the Pathogenesis of Viral Infections and Cancer, gene expression. These small regulatory RNAs have been shown to play essential roles in many important biological processes from metabolism to apoptosis. Alterations in miRNA expression profiles can have pathogenic consequences. This article will examine the role that miRNAs play in the pathophysio

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Oncogenic microRNAs in Cancer,el. Since the discovery of microRNAs, the number of microRNAs has kept growing over the past years. To date over 1,000 human microRNA precursors have been identified and registered (.). MicroRNAs exert their gene silencing function, usually by binding to the 3′-untranslated region (3′-UTR) of target

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Regulation of Metastasis by miRNAs,As (microRNAs). These microRNAs (miRNAs) control gene expression by acting on their target mRNAs, inducing either mRNA degradation or translational repression. MiRNAs are single-stranded and highly conserved between species. MiRNAs have been implicated in the detection and treatment of various patho

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MicroRNA in Leukemias,cytogenetically defined subtype of leukemia which play multifaceted roles in the genesis, pathobiology, progression and clinical outcome of this group of diseases. This chapter aims to provide a comprehensive review of the expression, regulation and cellular targets of the microRNAs in acute lymphob

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