Titlebook: Methods in Clinical Pharmacology—Central Nervous System; M. H. Lader,A. Richens Book 1981 Palgrave Macmillan, a division of Macmillan Publ

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The Clinical Assessment of Depression,opathology is ambiguous and consequently difficult to assess rationally. Depression presents fewer problems, most of which are soluble. It thus provides a useful paradigm for the discussion of clinical ratings in psychiatry.

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Sleep Studies in Clinical Pharmacology,ailments, may have unsuspected effects on the brain observable during sleep. I shall below take as a primary example the study in man of a drug expected to have hypnotic actions, following studies in animals and preliminary human testing.

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Tests of Autonomic Function in Assessing Centrally-Acting Drugs,al mechanisms of action. Nevertheless, studies of the peripheral autonomic actions of drugs of any therapeutic class are an important part of their early screening because they may be predictive of important adverse effects and drug interactions that may be encountered during their long-term therapeutic use.

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Clinical Assessment of Neuromuscular Transmission,oon recognised. By 1858 the drug had already been used in the management of tetanus and shortly thereafter albeit with less justification it had been employed in the treatment of a variety of diseases including chorea, epilepsy and hydrophobia.

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