Titlebook: Metastatic Bone Disease; An Integrated Approa R. Lor Randall Book 20161st edition Springer Science+Business Media New York 2016 Ablation te

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Bisphosphonates, Denosumab, and Anabolic Agents in the Treatment of Metastatic Bone Diseasebisphosphonates and the more-recent arrival denosumab. This chapter summarizes the mechanisms of action and modes of use in metastatic bone treatment of these drugs, along with their side effects and how these may be addressed.

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Biopsy Considerationsvaluation, enabling the determination of the tissue of origin and burden of skeletal disease. Regardless of whether the biopsy is performed in an open or percutaneous manner, the general principles of musculoskeletal biopsies are the same and must be respected for optimal patient outcome.

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Evaluation of the Patient with Carcinoma of Unknown Origin Metastatic to Bonefor carcinoma or to rule out primary bone sarcomas. Patients who present as a displaced pathologic fracture require an urgent diagnostic and treatment plan that does not compromise future treatment options and provides durable skeletal reconstruction.

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Pathobiology of Osteolytic and Osteoblastic Bone Metastasess that result in abnormal bone destruction and/or formation. This complex bidirectional interplay between tumor cells and bone microenvironment establishes a “vicious cycle” that leads to a selective growth advantage for the cancer cells. The molecular insights gained on the underpinnings of bone me

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