Titlebook: Metallopharmaceuticals I; DNA Interactions Michael J. Clarke,Peter J. Sadler Book 1999 Springer-Verlag Berlin Heidelberg 1999 Antigen.Bioan

GORGE

FRAX-tool

Anticancer Activity of Cisplatin and Related Complexes,as therapeutic limitations based primarily on toxic side effects and acquired resistance. The mechanism of action of cisplatin is under intense study in order to understand the chemical basis for these limitations and to develop in a rational manner a new generation of platinum-based antitumor drugs

悠然

Development of an Orally Active Platinum Anticancer Drug: JM216, programme of research was established between Johnson Matthey, the Institute of Cancer Research and Bristol Myers Squibb. Its aim was to discover and develop an orally active platinum drug possessing at least comparable antitumour activity to that of cisplatin but a toxicological profile reminiscen

可觸知

,-Platinum Compounds in Cancer Therapy: A Largely Unexplored Strategy for Identifying Novel Antitumtion for their antitumor activity have been reported. These “exceptions”, which frequently show activity against .-DDP-resistant cell lines, fall into three classes: 1) platinum(IV) complexes with the general formula .[PtC1.X.(L)(L’)] (X=hydroxide or carboxylate; L, L’=ammine or amine), 2) .-[PtC1.(

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Organization

Asseverate

Sulfoxide Ruthenium Complexes: Non-Toxic Tools for the Selective Treatment of Solid Tumour Metastass and the lack of significant host toxicity at pharmacologically active dosages. The complexes studied so far are characterised by the presence of dimethylsulfoxide ligands and, those which share the above properties, also by N-donor ligands on ruthenium (III) species. NAMI-A, [ImH][.-RuCl.(DMSO)Im]

septicemia

Non-Platinum Antitumor Compounds,o main-group metal or metalloid compounds, has been found and evaluated. Due to their different chemical characteristics, the mode of action and spectrum of activity of these compounds differ from each other. Antitumor activity in vitro is known for many compounds. Some compounds, like the ruthenium

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d social implications in human genomic research have not decreased but, on the contrary, have become accentuated at the same rate that new breakthroughs in the field of biomedicine get disseminated, and new private and national efforts are mobilized and consolidated to study and account for parts or

gout109

Andrew Gelasco,Stephen J. Lippardomplex diseases where environment and genetics are interacting within a dense and complex network. The development of new techniques and methodologies are making it possible to dissect and examine the etiology of complex diseases. Every month, from different areas (biochemistry, epidemiology, molecu