Titlebook: Messenger RNA Therapeutics; Stefan Jurga,Jan Barciszewski Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive licen

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Adjuvants, the Elephant in the Room for RNA Vaccines,rly understood. Although the attractiveness of mRNA as an immunogen has been recognized already more than thirty years ago, it wasn’t until the current COVID-19 crisis that its full potential was shown. From a fringe approach, it has now become a leading technology in vaccine development which will

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RNA/Polymer-Based Supramolecular Approaches for mRNA Delivery, a therapeutic modality, mRNA still has issues of poor bioavailability, showing rapid enzymatic degradation in physiological environments and inducing uncontrollable inflammatory responses. Chemical modification of mRNA is a prevalent approach to these issues and effectively reduces mRNA immunogenic

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Delivery Vehicles for Self-amplifying RNA,y into the cytosol. This amplification results in high protein expression from a relatively low dose of saRNA (~100-fold lower than mRNA). The rapid, cost-effective, cell-free manufacturing, low dosage requirement, and acceptable safety profile have drawn spotlight on saRNA, which has recently enter

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Nonsequential Pre-mRNA Splicing: From Basic Understanding to Impacts on Splice-Manipulating Therapies. The development of antisense oligonucleotides (AOs) to harness the splicing process and manipulate it to treat various inherited and acquired diseases has been boosted by its flexibility and customisation capability. As the amount of research in this space increases, certain aspects need to be c

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gical insights into diseases pathogenesis and therapeutic intervention. Herein, we introduce a quantitative strategy utilizing isobaric stable isotope-labeling techniques combined with two-dimensional liquid chromatography–tandem mass spectrometry (2D-LC–MS/MS) for large-scale, deep quantitative pro