Titlebook: Mesothelioma; From Research to Cli Giovanni Luca Ceresoli,Emilio Bombardieri,Maurizio Book 2019 Springer Nature Switzerland AG 2019 Lung tu

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Book 2019vival. However, advances in our understanding of the disease’s biology, together withthe availability of new drugs and combinations, make mesothelioma an essential and highly topical field for pre-clinical and clinical studies. .This book is subdivided into four parts: epidemiology and preclinical d

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Epidemiology of Mesothelioma,e in the large majority of cases. MM is nowadays the most important cause of death associated to asbestos exposure in the world, and its frequency has been increasing steadily, with over 38,000 deaths estimated each year. Forecasts of future epidemic indicate a reduction expected in the next years i

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Asbestos and the Pathophysiology of Mesothelioma,e. These characteristics and a relatively low price have contributed to the popularity of mining these inorganic substances at various locations in the world. In the beginning of the 1900s, a surge of asbestos use was noted in Europe, gradually followed by the rest of the world. The link between asb

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Genetics and Epigenetics of Mesothelioma,w to precision medicine. A few studies reported that the malignant pleural mesothelioma (MPM) genomic landscape is characterized by a much greater number of genomic losses than point mutations. Inactivating gene fusions, copy losses, and protein-truncating variants (PTVs) mostly affect tumor suppres

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Microenvironment and Immunology of the Human Pleural Malignant Mesothelioma,caused by the inhalation of airborne asbestos fibers. The local immunological network and especially inflammatory cells of the innate immunity play a major role in tumor onset and development, by fueling and perpetuating this state of non-resolving inflammation. Reactive oxygen and nitrogen species

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Preclinical Models in Mesothelioma,prove our knowledge of the disease so as to develop new therapeutic options. Different . and . models are available. Primary and immortalized cell lines are useful to study genomic alterations, to identify possible biomarkers, and to screen new drugs, but they do not reproduce the tumor microenviron

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Pathological Diagnosis of Mesothelioma,on morphological assessment, associated with clinical and radiological findings, and supported by immunohistochemistry as well as more recent molecular tests. This neoplasm displays a wide variety of histologic patterns and the major dilemmas consist in differential diagnosis with benign mesothelial

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