Titlebook: Meningococcal Vaccines; Methods and Protocol Andrew J. Pollard,Martin C.J. Maiden Book 2001 Springer Science+Business Media New York 2001 i

Protein

Book 2001the menace of the meningococcus has been high on the list of public health prio- ties. Few if any pathogens surpass the meningococcus in the rapidity and sev- ity with which it devastates previously healthy individuals. The challenge of understanding the biology of this fascinating microbe is immens

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Recombinant Proteins in Vaccine Development,lved in the preparation of recombinant class 1 OMP for vaccine development. This integrated set of methods can also be readily used to study the potential of other meningococcal OMP as vaccine candidates, and moreover, their utilities make them attractive for vaccine studies relating to many other human pathogens.

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1543-1894 the beginning of the twentieth centuries, the menace of the meningococcus has been high on the list of public health prio- ties. Few if any pathogens surpass the meningococcus in the rapidity and sev- ity with which it devastates previously healthy individuals. The challenge of understanding the bi

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Protein-Polysaccharide Conjugation,ection of the population most vulnerable to bacterial meningitis, and second, some polysaccharides are only weakly immunogenic in adults. To overcome these deficiencies, a new generation of semisynthetic vaccines have been developed based on the conjugation of polysaccharide to protein carriers.

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,-Propionylation,f α(2–8)-linked sialic-acid residues (.) and similar structures have also been identified in the humantissue antigens, from short trimeric fragments found in mammalian gangliosides (.) to long decameric fragments observed in the glycoproteins of neural-cell adhesion molecules (N-CAMs) (.).

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Identification of Peptides that Mimic , LOS Epitopes Via the Use of Combinatorial Phage-Display Libigopeptides to stimulate antibody responses that are cross-reactive with LOS antigens expressed by serogroup B . strains. An integral part of these studies has been the application of combinatorial phage-display technology. Described here is an overview of the methods that we have utilized to identify peptide mimics of LOS epitopes.

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