Titlebook: Memory T Cells; Maurizio Zanetti (Professor of Medicine),Stephen P Book 2010 The Editor(s) (if applicable) and The Author(s), under exclus

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0065-2598 ion of memory CD4 T cells.Discusses the role of cytokines, nImmunological memory has fascinated microbiologists and immunologists for decades as one of the new frontiers to conquer to better understand the response to pathogens, cancer and vaccination. Over the past decade, attention has turned to t

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The Role of Interleukin-2 in Memory CD8 Cell Differentiation,ignals during initial priming are able to mediate efficient secondary expansion following renewed antigenic challenge. Thus, IL-2 signals during different phases of an immune response are key in optimizing CD8. T-cell functions, thereby affecting both primary and secondary responses of these T cells

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Longevity of T-Cell Memory following Acute Viral Infection,ollowing infection. As a result of this work, we have gained a broader understanding of the kinetics and magnitude of antiviral T-cell immunity as well as new insight into the patterns of immunodominance and differential regulation of cytokines and cytotoxicity-associated molecules. This information

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Principles of Memory CD8 T-Cells Generation in Relation to Protective Immunity,s to enable protective memory T cells by vaccination we address vaccination both in the context of the immunologically-inexperienced and immunologically-experienced individual, respectively. Finally, we draw attention to the interplay between systemic and local immunity as important factors in deter

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Memory T Cells in Rhesus Macaques,ll focus on the distribution of memory cells in the different immunologic compartments of Rhesus macaques. In addition, the strategies available to manipulate memory cells in Rhesus macaques to understand their trafficking and function will be discussed. Emphasis is placed on studies of memory cells

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Memory T-Cell Responses and Survival in Human Cancer: Remember to Stay Alive,y the absence of early signs of metastatic invasion (lymphovascular emboli) correlated with a significant increase of the density of memory T cells in situ. This chapter presents the arguments supporting the existence of immunosurveillance mechanisms in human cancer. We will discuss the potent role

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0065-2598 ry T cells are generated, maintained and expanded upon re-encounter with antigen. Ultimately, these studies are all aimed at a better understanding of the function of memory T cells in protection against disease.978-1-4939-4103-2978-1-4419-6451-9Series ISSN 0065-2598 Series E-ISSN 2214-8019

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Ivana Munitic,César Evaristo,Hsueh Cheng Sung,Benedita Rocha