Titlebook: Membrane Transporters in Drug Discovery and Development; Methods and Protocol Qing Yan Book 2010 Humana Press 2010 In silico.PCR.bioinforma

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Analysis of Expression of Drug Resistance-Linked ABC Transporters in Cancer Cells by Quantitative R accurate and reproducible detection of transcript levels. As a consequence, qRT-PCR has become a popular technique for assessing gene expression levels and is now the gold standard. In this chapter, qRT-PCR using two distinct chemistries, SYBR Green and TaqMan, are described. We compare ABC transpo

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Fluorescence Studies of Drug Binding and Translocation by Membrane Transporters,d uptake in the intestine and cannot gain access to the brain. Three multidrug efflux pumps of the ABC superfamily (P-glycoprotein/ABCB1, MRP1/ABCC1, and BCRP/ABGG2) are responsible for most drug transport out of mammalian cells. P-glycoprotein is the best characterized of the ABC drug transporters.

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ABC Transporters in Ophthalmic Disease,maculatus, cone–rod dystrophy, retinitis pigmentosa, and age-related macular degeneration. The genetic and molecular pathways involved in the pathogenesis of ABCR-related ophthalmic conditions will be explored. Future diagnostic and therapeutic objectives for these diseases will also be discussed.

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Imaging of Protein Translocation In Situ in Skeletal Muscle of Living Mice,k of insulin-resistant states and type II diabetes. Therefore it is highly pathophysiologically relevant to perform detailed studies of insulin signaling inside skeletal muscle cells in order to elucidate the specific molecular events during both normal and insulin-resistant conditions. So far, cell

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Glucose Transporters in Parasitic Protozoa,agents of leishmaniasis, African sleeping sickness, and malaria. Glucose transporters and the genes that encode them have been identified in each of these parasites and their functional properties have been scrutinized. These transporters are related in sequence and structure to mammalian facilitati

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