Titlebook: Melanoma Antigens and Antibodies; Ralph A. Reisfeld,Soldano Ferrone Book 1982 Plenum Press, New York 1982 antibody.antigen.cancer.cancer r

Affectation

Indomethacin, Prostaglandin, and Immune Regulation in Melanoma,la ..,1977). It has been assumed that this decreased immunocompetence is due to a deficiency of effector-cell function (e.g., antibody-forming B lymphocytes, cytotoxic T lymphocytes). Such a concept led to a strategy of immunotherapy; manipulations with the goal of . the immune system to correct the

HEED

Shedding and Degradation of Cell-Surface Macromolecules and Melanoma-Associated Antigens by Human Mstimulate immune responses and thus increase resistance to cancer. Conversely, alone or in complex with antibodies, they may interfere with humoral and cellular immune destruction of malignant cells and thus may enhance tumor growth. Since these effects can be mediated by soluble tumor antigens, the

entrance

Monoclonal Antibodies as a Tool to Detect Melanoma-Associated Antigens, allogeneic or autologous sera have been used (Gupta and Morton, 1975; Lewis .., 1979; Carey .., 1976; Liao ..,1978; Shiku .., 1976, 1977; Cornain .., 1975; Ferrone and Pellegrino, 1977; Hersey .., 1976; Morton .., 1968; Muna .., 1969). In addition, immunization of rabbits, guinea pigs, and monkeys

Trigger-Point

Tumor-Directed Cellular Immunity in Malignant Melanoma and the Antigens That Evoke It,ot as uniformly bad as was previously believed by the medical profession and the informed laity (Solzhenitsyn, 1968). In favorable groups of patients with small superficial tumors [< 0.76 mm by micrometric measurement (Breslow, 1970)], the cure rate may considerably exceed 50%. Even in patients with

掃興

Heterogeneity of Human Melanoma-Associated Antigens Revealed by Alloantisera and Xenoantisera,ental questions have been raised in this model, and reliable answers may now be emerging. These questions include the following: (1) Do human tumor-specific antigens that function as rejection antigens exist? (2) Are these antigens immunogenic in man, and if they are, how should they be measured? (3

GRAIN

Protein Antigens of Mouse Melanomas,tright to B16 preparations—either whole-cell (Fidler .., 1977) or extract (Bystryn, 1978). The second is that cultured cells, when injected into B16-sensitized hosts, exhibit . behavior different from that observed following administration into na?ve hosts (Fidler ..,1977; Gersten, 1980). It follows

circumvent

BRIBE

螢火蟲

Expertise

The Nature and Significance of Melanoma Antigens Recognized by Human Subjects, sera of patients with melanoma. These studies have raised considerable controversy that centered initially on the cross-reactivity of antigens detected by human antisera between different melanoma cells and then on both the biological and biochemical nature of these antigens. With the application o