Titlebook: Medizinprodukte als Hilfsmittel in der gesetzlichen Krankenversicherung; Theresa Wabnitz Book 2009 Springer-Verlag Berlin Heidelberg 2009

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the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens. Cisplatin is still an irreplaceable component of a regimen that produces high cure rates in even advanced nonseminomatous germ-cell cancers, and is widely used in the t

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d in Verona, Italy, from November 30th to December 3rd 2007.Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a ce

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the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens. Cisplatin is still an irreplaceable component of a regimen that produces high cure rates in even advanced nonseminomatous germ-cell cancers, and is widely used in the t

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ne). (1,2). The reaction of these Pt-compounds with DNA occurs in a two-step mechanism. The first binding step consists exclusively of binding to guanine at the N7 position. The second binding step depends on the kind of neighbouring base of the coordinated guanine. When this base is another guanine

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