Titlebook: Mechanisms of Viral Pathogenesis; From Gene to Pathoge A. Kohn,P. Fuchs Conference proceedings 1984 Martinus Nijhoff Publishing, Boston 198

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Host Range Transition of Lymphotropic Minute Virus of Mice During Persistent Infection in L-Cellsrty of the progeny virus, suggesting that it is genetically determined. Restriction endonuclease analysis failed to detect differences between the mutant viral DNA and that of MVM(i), indicating that the host range determining region in the viral genome is small.

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Transplantation of Mouse Genes into Rat Cells Chronically Infected by Moloney Murine Leukemia Virus viruses, and causes inhibition of 97 per cent of M.-MuLV release. These properties are observed only in rat cells chronically infected with M.-LV obtained from mouse, but not in those infected with Moloney Leukemia Virus obtained from rat (M.-RLV).

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Pathogenic Aspects of Murine Coronavirus Infection in Ratson. In rats, the disease course is of remitting and relapsing nature accompanied by demyelination. Virological and immunological studies suggest that the persistent virus infection in brain tissue induces an autoimmune response to brain antigens which contribute to the disease process.

情感脆弱

Rearrangement and Activation of a Cellular Oncogeneand it involved the insertion of an endogenous retroviral (intracisternal A-particle) genome. The 5’ viral long terminal repeat, placed next to . coding region, probably acts as an enhancer-promoter element.