Titlebook: Mechanisms of Vascular Disease; A Textbook for Vascu Robert Fitridge Textbook 2020Latest edition Springer Nature Switzerland AG 2020 Arteri

RLS898

Hypercoagulable States,thrombophilia. Inherited thrombophilic conditions can be divided into type 1 conditions that involve a deficiency of naturally occurring inhibitors of coagulation (antithrombin, protein C and protein S), and type 2 conditions that result in a gain of function in a procoagulant protein (prothrombin g

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Pathophysiology and Principles of Management of Hereditary Aneurysmal Aortopathies,ing for 1–2% of all deaths in the Western population. Thoracic aortic aneurysms (TAAs) have been more extensively studied than their abdominal counterparts because of greater heritability and earlier disease onset. Hitherto, mutations in more than 30 genes have been linked to TAA development. In gen

troponins

Pathophysiology, Classification and Principles of Management of Acute Aortic Syndromes, recognized and understood by modern vascular surgeons. The more modern nuances of approach to the diagnosis, classification and management of AAS are outlined, including various classification systems, and underlying pathological processes of the disease. A brief overview of medical management stra

conjunctivitis

Biomarkers in Vascular Disease,ses such as inflammation, apoptosis, proteolysis, thrombosis, and extracellular matrix degradation have been described in the aetiology of both aneurysmal and atherosclerotic disease. As a consequence of these processes, local cytokine, enzyme and protein expression is modified. Today, many of these

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Sepsis and Septic Shock,oad-ranging dysregulation of cardiovascular, coagulation, neuronal, bioenergetic, endocrine and other systems. Unchecked, sepsis can culminate in cardiovascular collapse, multi-organ failure and death. The most common sources of sepsis in critically unwell patients are the respiratory tract, abdomen

nerve-sparing

Pathophysiology of Reperfusion Injury,ow to ischaemic tissues. Whilst reperfusion is required for tissue/organ viability, the return of oxygen to the tissue induces a complex multi-factorial process involving oxidative stress and inflammatory changes..IRI occurs in a wide range of organs and conditions, most significantly affecting the

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