Titlebook: Mechanisms of Stimulus—Response Coupling in Platelets; J. Westwick,M. F. Scully,V. V. Kakkar Book 1985 The Editor(s) (if applicable) and T

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Control and Interrelation of Aggregation and Secretion; the Roles of Ca2+, Diacylglycerol and Thromb and the various ways in which secretion and aggregation may be independent or interdependent under different experimental conditions. We shall also consider briefly shape-change and its relation to aggregation and secretion.

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Permeabilised Platelets and Exocytosisation in Ca. concentration and the nature of various factors which may modulate these responses. Permeabil-isation is achieved by exposure of a suspension of platelets to a series of intense electric fields, a treatment that seems to cause localised dielectric membrane breakdown.. The basis for the

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Platelet Membranes, Eicosanoid Biosynthesis and Putative Endogenous Calcium Ionophoress and the sequence of metabolic events involved in mobilisation of arachidonic acid (AA) from membrane phospholipids; it is important to be able to separate subcellular fractions representative of surface membrane (SM) and membranes of intracellular origin (IM). In the case of the platelet, such pre

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Nucleate

Energy Requirements for Stimulus-Response Couplingutely dependent on the availability of ATP (1,2,3). This dependency may be due to ATP-requiring processes that 1) maintain the platelet in responsive state, 2) are involved in the stimulus-response coupling sequence and 3) drive the individual responses (Fig. 1). One way to indicate whether ATP cons

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Platelet Protein Phosphorylationany other cells.. It is pertinent to ask why this should be? There are probably two major reasons. First the addition of the phosphate group to a protein adds, though a fairly simple reaction, a substituent group which can substantially change the character of the protein, its conformation and its i