Titlebook: Mechanisms of Gene Regulation: How Science Works; Carsten Carlberg,Ferdinand Molnár Textbook 2020 Springer Nature Switzerland AG 2020 Tran

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Basal Transcriptional Machinery,s not a single defined nucleotide. The basal transcriptional machinery interacts . another multi-protein complex of co-activators, termed the Mediator complex, with a large variation of transcription factors. In parallel, the Mediator complex coordinates the action of co-activators and co-repressors, some of which are chromatin modifiers.

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Epigenetics, intra- and inter-chromosomal contacts and in this way to stabilize 3D complexes of chromatin loops. CTCF-mediated loops at several developmentally regulated loci provide a mechanistic explanation of genomic imprinting.

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