Titlebook: Mechanisms and Models in Toxicology; Proceedings of the E Claire M. Chambers,Philip L. Chambers,Donald S. Da Conference proceedings 1987 Sp

indigenous

ATP861

Oxidative and Reductive Biotransformation of Chloroform in Mouse Liver Microsomesr, however, to assess its carcinogenic power in man, who may be exposed for long periods to CHC1. present in drinking water and the work environment. Thorough metabolic studies would be of particular importance to establish the dose dependency of the carcinogenic effect; indeed, a great deal of unce

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Effects of Subchronic Low-Protein Diet on Some Tissue Glutathione - Related Enzyme Activities in the 1976; Mag-dalou et al. 1979). Deficiency of protein decreases the activity of the mixed-func-tion oxidase system (cf. Hathcock 1985). Since glutathione (GS) and GS-related enzymes play an important role in the detoxification processes, the influence of subchronic low-protein diet (LPD) on GS conten

AVID

Interorgan Shift of Nitrosamine Metabolism by Dietary Ethanolructure activity investigations have established that symmetric nitrosamines are often hepatocar-cinogens, whereas most asymmetric nitrosamines selectively induce esophageal carcinomas. Furthermore, dibutylnitrosamine and related long-chain nitrosa-mines cause the development of bladder tumors while

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Temporal-Lobe

填滿

A Postlabelling Assay for N7-(2-Oxoethyl)Guanine, the Principal Vinyl Chloride-DNA Adduct82; Creech and Johnson 1974; Spirtas and Kaminski 1978). A programme of studies in this laboratory is investigating the relationships between exposure to VC, the dose at critical cellular targets, e.g. DNA, and the carcinogenic response in experimental species, e.g. rat. A key aspect of this work ha

Awning

Comparison of Hydrocarbon – DNA Adducts Formed in Mouse and Human Skin Following Treatment with Benzative differences may exist between the bioactivation of carcinogens in man and experimental species employed as prospective risk models (Gori 1980; Wright 1980, 1981, 1983). By studying the interactions between DNA and metabolites of precursor carcinogens, the investigation of qualitative and, poss

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