Titlebook: Mechanism of Muscular Contraction; Jack A. Rall Book 2014 American Physiological Society 2014 Human physiology.Muscle physiology.Muscular

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Jack A. RallDescribes the evolution of muscular contraction concepts since the discovery of sliding filaments.Includes detailed scientific histories of principal investigators in the field.Features information on

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,1972 Cold Spring Harbor Symposia on Quantitative Biology: The Mechanism of Muscle Contraction—Problrew Huxley, Hugh Huxley and Andrew Szent-Gyorgyi. In the forward to the published volume, Watson explained the purpose of the Cold Spring Harbors Symposia on Quantitative Biology and why muscle was “ripe” for selection as the 37th symposium.

Autobiography

Book 2014zing variety of experimental techniques have been employed to investigate the mechanism of muscular contraction and relaxation.?Some background of these various techniques is presented in order to gain a fuller appreciation of their strengths and weaknesses.?Controversies in the muscle field are dis

ANIM

Glory Days: Establishment of the Sliding Filament Model of Muscular Contraction in the 1950s and 19roscopy nor Hugh Huxley’s electron micrographs from longitudinal muscle sections were good enough to trace a single thin filament from the Z line into the A band where it was presumed to overlap with the thick filaments.

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Birth of the Sliding Filament Model of Muscular Contraction: Proposal,s in the cross-striations of muscle during contraction and stretch and their structural interpretation”. But the story of sliding filaments begins before May 22, 1954. In order to understand and appreciate the experiments that were done and why they were done, it is necessary to review the scientific background of each of the investigators.

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